2020 Latest Design Sucrose Pharmaceutical Excipient - n-methylbenzamide|CAS 613-93-4|C8H9NO|Guanlang – Guanlang

We are one of the leading n-methylbenzamide suppliers and manufacturers in china, if you want to find n-methylbenzamide factory, feel free to contact us and drop us a email.

1. What’s  N-Methylbenzamide?

N-methylbenzamide is an effective phosphodiesterase 10A (pde10a) inhibitor. N-methylbenzamide has anticancer activity.PDE10A is a recently identified phosphodiesterase with a quite remarkable localization since the protein is abundant only in brain tissue. Based on this unique localization, research has focused extensively on using PDE10A modulators as a novel therapeutic approach for dysfunction in the basal ganglia circuit including Parkinson’s disease, Huntington’s disease, schizophrenia, addiction and obsessive compulsive disorder. Medicinal chemistry efforts identified the N-methyl-N-[4-(quinolin-2-ylmethoxy)-phenyl]-isonicotinamide as a nanomolar PDE10A inhibitor. A subsequent Lead-optimization program identified analogous N-methylanilides and their corresponding N-methylbenzamide as potent PDE10A inhibitors, concurrently some interesting and unexpected binding modes were identified.

Melting point 76-78 ° C

Boiling point 167 ° C

Density 1.1031

Refractive index 1.5589

Storage conditions sealed dry, room temperature

Solubility ethanol: soluble 50mg / ml,water solubility:Insoluble in Water

CAS: 613-93-4

Appearance: White Crystalline

2. Main application

Inhibitor, anticancer,organic synthesis intermediate,laboratories chemicals

3.Storage and Packing

3.First aid measures

Eye Contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention.

Skin Contact: Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes.

Inhalation: Remove from exposure, lie down. Remove to fresh air. If not breathing, give artificial respiration.

Ingestion: Clean mouth with water. Get medical attention.

Most important symptoms and effects: No information available.

Self-Protection of the First Aider: No special precautions required.

Notes to Physician: Treat symptomatically.

4.  Transport information

Road and Rail Transport : Not Regulated

IMDG/IMO : Not regulated

IATA : Not regulated

Special Precautions for User: No special precautions required

5. HTML5 spectrum

Hebei Guanlang Biotechnology Co., Ltd. belongs to Guanlang Group, which was founded in 2007 , located in Shijiazhuang city which is the capital of Hebei Province and hub sector among Beijing Tianjin and Hebei and has advantage of convenient transportation . Our company is a modern high-tech chemical enterprise with Research & Development, production and sales.We have our own factory and lab,also offer customized synthesis service for our customers.